Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency.
J Allergy Clin Immunol. 2016 Aug 13;
Authors: Driessen GJ, IJspeert H, Wentink M, Yntema HG, van Hagen PM, van Strien A, Bucciol G, Cogulu O, Trip M, Nillesen W, Peeters EA, Pico-Knijnenburg I, Barendregt BH, Rizzi M, van Dongen JJ, Kutukculer N, van der Burg M
Abstract
PTEN deficiency in humans is associated with PTEN Hamartoma Tumor Syndromes (PHTS). It causes increased activation of the PI3K/Akt pathway and we here show that the humoral immune response is deregulated resulting in CSR and SHM deficiency. This is clinically apparent in part of the PHTS patients as antibody deficiency. In conclusion, PI3K/Akt signaling is important for the human B-cell response to antigens and deregulated signaling is implicated in the pathophysiology of antibody deficiency.
PMID: 27531073 [PubMed – as supplied by publisher]
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