A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum.
Infection. 2017 Aug 18;:
Authors: van de Vosse E, van Wengen A, van der Meide WF, Visser LG, van Dissel JT
CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum.
CONCLUSION: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies.
PMID: 28822097 [PubMed – as supplied by publisher]
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