Truly selective primary IgM deficiency is probably very rare.
Clin Exp Immunol. 2017 Oct 06;:
Authors: Janssen LM, Macken T, Creemers MC, Pruijt JF, Eijk JJ, de Vries E
Abstract PMID: 28984901 [PubMed – as supplied by publisher] Powered by WPeMatico
Isolated decreased serum-IgM has been associated with severe and/or recurrent infections, atopy and autoimmunity. However, the reported high prevalence of clinical problems in IgM-deficient patients may reflect the skewed tertiary center population studied so far. Also, many papers on IgM-deficiency have included patients with more abnormalities than just IgM-deficiency. We studied truly selective primary IgM deficiency according to the diagnostic criteria of the European Society for Immunodeficiencies ESID (true sIgMdef) by reviewing the literature (261 patients with primary decreased serum-IgM in 46 papers) and retrospectively analyzing all patients with decreased serum-IgM in a large teaching hospital in ‘s-Hertogenbosch, the Netherlands (1-July-2005 to 23-March-2016; n=8,049 IgM<0.4g/l; n=2,064 solitary [IgG+IgA normal/IgM
PMID: 28984901 [PubMed – as supplied by publisher]
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